Conclusion first: Hexacosanol, Octacosanol and Triacontanol are neighboring straight-chain primary fatty alcohols, but they are not interchangeable. From C26 to C28 to C30, only two carbons are added at each step, yet molecular weight, lipophilicity and melting behavior rise—changing processing and formulation choices.
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Hexacosanol is C26H54O, Octacosanol is C28H58O, and Triacontanol is C30H62O. Each step adds C2H4 and about 28 g/mol. PubChem gives molecular weights of about 382.7, 410.8 and 438.8 g/mol.
Constant: one terminal hydroxyl group. Changing: chain length, molecular weight, hydrophobic contribution and crystal packing.
| Property | Hexacosanol | Octacosanol | Triacontanol |
|---|---|---|---|
| Carbon number | C26 | C28 | C30 |
| CAS No. | 506-52-5 | 557-61-9 | 593-50-0 |
| Molecular weight | 382.7 | 410.8 | 438.8 g/mol |
| PubChem XLogP3 | 12.7 | 13.8 | 14.9 |
| Polar surface area | 20.2 Ų | 20.2 Ų | 20.2 Ų |
| Representative TCI melting range* | 78–81 °C | 81–85 °C | 85–90 °C |
The useful pattern is directional: the –OH head remains unchanged while the hydrocarbon chain grows. PubChem XLogP3 rises from 12.7 to 14.9 while polar surface area stays at 20.2 Ų, showing increasing lipophilic character from C26 → C30.
*TCI values are representative grade specifications, not universal constants. Purity, homolog distribution and test method can shift an observed melting range.
Melting behavior affects melt incorporation, oil-phase dissolution and crystallization during cooling. Moving from C26 toward C30 may require a different thermal window or carrier system. In aqueous or semi-aqueous systems, particle size and emulsifier choice may matter as much as assay. Higher purity does not automatically mean easier formulation.
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Octacosanol is established as a nutritional/functional ingredient; Triacontanol is widely studied as a plant growth regulator; Hexacosanol is often evaluated as a homolog-specific high-carbon fatty alcohol. Their shared family does not imply the same formulation or qualification route.
Because neighboring C26/C28/C30 homologs are chemically similar, buyers should confirm whether a percentage refers to the target monomer or a broader total alcohol fraction. A headline purity value cannot replace a clear GC profile.
HUZHOU SIFENG BIOCHEM CO., LTD states that its platform covers C24–C34 fatty alcohol monomers and mixtures. It lists Octacosanol SF-002 from 10% to 90%, Triacontanol SF-003 at 90% and 95%, and Hexacosanol at 90% and 95%. For sourcing, homolog control and application fit matter more than asking which carbon number is “better.”
Share target alcohol, assay, application, annual volume and destination market before sample qualification.
HUZHOU SIFENG BIOCHEM CO., LTD · sales@sifengbio.com
